I am a skeptic when it comes to these products. I am also patient. Most of all I am cautious. I don't mind speeding up what takes place establishing a nitrogen cycle. I've done this many times starting fishtanks. I do a fishless cycle by first spiking my water with a chemical....ammonia. I use ordinary household, no frills, plain ammonia. Usually a bottle that says the words under ingredients "ammonia and water". Of course it has no scents added and no soaps. I shake the bottle in question good to make sure it doesn't sud. Since there are no fish, I spike the ammonia until it tests 4 ppm. Then I add media from an already existing tank to the new filter to "seed" it. I have established a cycle in as little as 3 days and as long as 28 using this method. It is "natural" because it is existing bacteria, but transfered. I would not have a problem using a product that had the type of bacteria that is live or suspended somehow. There was a product that was proven to work called Bio-Spira. I have recently learned that the formula has changed to a formula that doesn't have to be refridgerated. Along with that, the scientist who invented it for Marineland has left and started his own company and further research into "bacterias in a bottle". The skepticism in most of these products is if they really work. I myself have tested a few that made these claims and none of them did squat. I tested 2 new 10 gallon tanks, with identical filters. One with the product, the other without. I followed the products directions to the letter. None did anything. I never tried Bio-Spira, but a friend, talk about skeptics, that I trust has, and it worked. The products I tested where bio-zyme, cycle, and a couple that I don't even remember their names....none worked. Out of curiosity I am going to pick up some of the microbe lift gel. Only $11, shipping will be free because I have other stuff I am ordering. I don't mind giving things a chance, but right off the bat I don't like the claims it makes. That doesn't mean it wont work, just don't like their choice of words. It sends up a red flag.